deanlab

our GROUP

Our workgroup is based at the Max Planck Institute Department of Biomaterials @

the Max Planck Institute of Colloids & Interfaces in Potsdam, Germany 

​

We have ongoing projects with a variety of regular collaborators, at the Wyss Institute for Bioinspired Design at Harvard, the Zuse Institute for Information Technology in Berlin and other institutions

 

In 2019, we begin collaboration with the Matters of Activity Research Excellence Cluster

our WORK

We investigate principles of organization and performance in animal musculoskeletal systems —particularly in fishes— to address questions relevant to ecology, evolution, physiology and behavior, also incorporating engineering and physical science perspectives to inform biomaterials and translational science. 

 

Mouse-over images below to learn more about the techniques we use to investigate development and form-function relationships in animals, from tissues up to whole skeletal elements.

[Please ask me before using any of these images.]

our PUBLICATIONS

See my ResearchGate page for our full publication list and PDFs

Please contact me for my complete CV

recent PUBLICATIONS

• Seidel, R, A Roschger, L Li, JJ Bizzarro, Q Zhang, J Yin, T Yang, JC Weaver, P Fratzl, P Roschger & MN Dean (2019) Mechanical properties of stingray tesserae: High-resolution correlative analysis of mineral density and indentation moduli in tessellated cartilage. Acta Biomaterialia. (In press)

​

• Baum, D, JC Weaver, I Zlotnikov, D Knötel, L Tomholt & MN Dean (2019) High-throughput segmentation of tiled biological structures using random walk distance transforms. Integrative & Comparative Biology. (In press)

​

• Ofer, L, MN Dean, P Zaslansky, S Kult, Y Shwartz, J Zaretsky, S Griess-Fishheimer, E Monsonego-Ornan, E Zelzer & R Shahar (2019) A novel non-osteocytic regulatory mechanism of bone modeling. PLoS Biology. 17(2): e3000140. (DOI: https://doi. org/10.1371/journal.pbio.3000140)

 

• Hosny A, S Keating, J Dilley, B Ripley, T Kelil, S Pieper, D Kolb, C Bader, A Pobloth, M Griffin, R Nezafat, G Duda, E Chiocca, J Stone, J Michaelson, MN Dean, N Oxman & JC Weaver (2018) From improved diagnostics to presurgical planning: High-resolution functionally graded multimaterial 3D printing of biomedical tomographic data sets. 3D Printing & Additive Manufacturing. 5(2): 1-11. (DOI: 10.1089/3dp.2017.0140)

        » Media coverage: 3D Printing Industry | Phys.org | Wyss Institute

​

• Knoetel D, R Seidel, S Prohaska, MN Dean & D Baum (2017) Automated segmentation of complex patterns in biological tissues: Lessons from stingray tesselated cartilage. PLoS ONE. 12(12): e0188018. (DOI: 10.1371/journal.pone.0188018)

 

• Seidel R, M Blumer, E-J, Pechriggl, K Lyons, BK Hall, P Fratzl, JC Weaver & MN Dean (2017) Cartilage or bone? Collagens in the skeleton of “cartilaginous” fishes answer an old question. Journal of Structural Biology. 200(1): 54-71. (DOI: 10.1016/j.jsb.2017.09.005).

 

• Dean MN, J Bizzarro, B Clarke, CJ Underwood & Z Johanson (2017) Large batoid fishes frequently consume stingrays despite skeletal damage. Royal Society Open Science. 4: 170674. (DOI: 10.1098/rsos.170674).

        » Media coverage: Deutschlandfunk        | Max Planck Society DE/EN | Natural History Museum

 

• Seidel R, M Blumer, P Zaslansky, D Knötel, DR Huber, JC Weaver, P Fratzl, S Omelon, L Bertinetti, MN Dean (2017) Ultrastructural, material and crystallographic description of endophytic masses - a possible damage response in shark and ray tessellated calcified cartilage. Journal of Structural Biology. 198: 5-18. (DOI: 10.1016/j.jsb.2017.03.004).

 

• Jayasankar AK, Seidel R, Guiducci L, Hosny A, Fratzl P, Weaver JC, Dunlop JWC & MN Dean (2017) Mechanical behavior of idealized, stingray-skeleton-inspired tiled composites as a function of geometry and material properties. Journal of the Mechanical Behavior of Biomedical Materials. 73: 86-101 (DOI:10.1016/j.jmbbm.2017.02.028).

 

• Frølich S, JC Weaver, MN Dean, H Birkedal (2017) Uncovering nature's design strategies through parametric modeling, 3D printing, and mechanical testing. Advanced Engineering Materials. 19: 1600848. (DOI: 10.1002/adem.201600848)

       » Media coverage: Advanced Science News | 3D Printing Industry

 

• Priemel T, E Degtyar, MN Dean & MJ Harrington (2017) Rapid self-assembly of complex biomolecular architectures during mussel byssus bio-fabrication. Nature Communications. In press. (DOI: 10.1038/NCOMMS14539)

 

• Currey JD, MN Dean, R Shahar (2017) Revisiting the links between bone remodeling and osteocytes: insights from across phyla. Biological Reviews. 92: 1702–1719. (DOI: 10.1111/brv.12302)

 

• Albéric M, MN Dean, A Gourrier, W Wagermaier, JWC Dunlop, A Staude, P Fratzl & I Reiche (2017) Relation between the macroscopic pattern of elephant ivory and its three-dimensional micro- tubular network. PLoS One. 12(1): e0166671. (DOI: 10.1371/journal.pone.0166671)

 

• Seidel R, K Lyons, M Blumer, P Zaslansky, P Fratzl, JC Weaver & MN Dean (2016) Ultrastructure and ontogeny of the mineralized skeleton of cartilaginous fishes. Journal of Anatomy. 229(5): 681-702. (DOI: 10.1111/joa.12508)

 

• Fratzl P, O Kolednik, FD Fischer, MN Dean (2016) The mechanics of tessellations – bioinspired strategies for fracture resistance. Chemical Society Reviews – Invited Tutorial Review. 45: 252-267. (DOI: 10.1039/C5CS00598A)

 

• Kolmann MA, SB Crofts, MN Dean, AP Summers, & NR Lovejoy (2015) Morphology does not predict performance: jaw curvature and prey crushing in durophagous stingrays.  Journal of Experimental Biology. 218: 3941-3949. (DOI: 10.1242/jeb.127340)

 

• Dean, MN, L Ekstrom, J Ballantyne, E Monsonego Ornan, PE Witten, W Habraken, C Riley & S Omelon (2015) Mineral homeostasis and regulation of mineralization processes in the skeletons of cartilaginous fishes. Seminars in Cell and Developmental Biology – Invited Review. 46: 51–67. (DOI:10.1016/j.semcdb.2015.10.022)​

 

 

BOOK CHAPTERS & CONTRIBUTIONS

• Seidel R, A Jayasankar, R Shahar & MN Dean (2019) Multiscale architectures of fish bone and tessellated cartilage and their relation to function. In: Architectured Materials in Nature and Engineering (eds. Y Estrin, Y Bréchet, JWC Dunlop, P Fratzl) Springer Series in Materials Science, vol 282. New York, NY. pp. 329-353. (Invited book chapter)

 

• Huber DR, CAD Wilga, MN Dean, L Ferry, J Gardiner, L Habegger, Y Papastamatiou, J Ramsay & L Whitenack (2019). Feeding in cartilaginous fishes: An interdisciplinary synthesis. In: Feeding in Vertebrates – Anatomy, Biomechanics, and Evolution (ed. V Bels, IQ Whishaw) Springer Publishing. New York, NY. pp. 231-295. DOI: 10.1007/978-3-030-13739-7_8 (Invited book chapter)

 

• Dean, MN (2017) Cartilaginous Fish Skeletal Tissues. In: Reference Module in Life Sciences, Elsevier, ISBN 9780128096338. (Invited book chapter)

 

• Claeson KM & MN Dean (2017) Cartilaginous Fish Skeletal Anatomy. In: Reference Module in Life Sciences, Elsevier, ISBN 9780128096338. (Invited book chapter)

 

• MN Dean & A Hosny (2016) Analyse der Kachelstruktur des Knorpelfisch-Skeletts. In: +ultra. gestaltung schafft wissen (ed. N Doll, H Bredekamp, W Schäffner). pp. 240-1. Leipzig: E.A. Seemann, ISBN 978-3-86502-378-0. (Invited contribution)

 

 

...Please see my ResearchGate page for more of our publications...